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PRP (Platelet Rich Plasma) therapy is to undergo the centrifugation of the blood taken from the patient, to physically concentrate and inject the target tissue in order to obtain fast tissue rejuvenation and healing. PRP is in liquid form.

CGF (Concentrated Growth Factor) therapy is to perform tissue renewal by injecting concentrated growth factor plasma into the patient by physically or chemically activating the platelet plasma (doing activation while in the tube) by centrifuging the blood sample taken from the patient. While activation in PRP starts in tissue after injection, it takes place in the tube during CGF process.

PRF (Platelet Rich Fibrin) therapy is to obtain Fibrin-rich plasma by centrifuging the blood sample taken from the patient and running the clot mechanism. It is obtained as a clotted product in plasma gel consistency in PRF. Platelet rich part is taken and mixed with bone graft and applied to the target tissue.


PRP, CGF and PRF treatment methods are actually built on exactly the same basis. The treatment origin is to create tissue regeneration by using the growth factors in the platelets in all three applications. The differences between these treatments are due to differences in the methods of obtaining plasma.

PRP History

It was first used in 1987 in open heart surgery.

PRP gained popularity after being applied to well-known NBA players in the 1990s.

How Rich should Platelet Rich Plasma be?

In Clinical Studies, the therapeutic threshold in PRP should be 1,000,000 plt / μl.

PRP Treatment Physiology

How should the centrifuge device be?

✔ Flying Rotor

✔ No vibration

✔ Should be set accordinf to RCF

✔ Cooling and UV Sterile

How much and How to take PRP?

Buffy Coat = PLT + Leukocyte

If 1/4 dilution intake is made in 15 ml blood, a total of 1.5-2 ml

PRP should be taken and applied to the target point.

The remaining PPP can be taken and applied around the

target point separately.

In clinical publications and scientific studies
PRP Activity was found to be directly proportional to ASPIRATION TECHNIQUE & CONCENTRATION and DOSAGE.

Important Warnings

  • The right patient should be chosen
  • Thick needle can be preferred while taking from the tube, and fine needle can be preferred when applying.
  • Total number> 1.000.000 μl (Correct Kit & Aspiration Technique)
  • LA & Steroids change ambient PH and Effect is reduced
  • NSAII should not be taken 3 days before – 1 week later
  • Blood thinners should not be taken until 3 days before and 1 day after.
  • PRP is an auxiliary treatment method. REHABILITATION after PRP is very important.